Marathon Running: The macroevolution and continued adaptation of a ‘uniquely human trait’

by Anne Kessler

evolutionofRunning

source: spiritedthoughts.wordpress.com/2011/06/23/nature-can-take-care-of-itself/

According to the fossil record, endurance running capabilities first evolved roughly two million years ago, approximately four million years after the initial evolution of bipedal walking – a divergent moment in evolutionary history leading up to the human species. Fast forward to present time. In America alone, over 500,000 people complete at least one marathon in a given year. Because many people run races of distances that exceed 26.2 miles (ultra-marathon) and many runners never register for official races, the actual number of endurance runners in America likely exceeds one million people. Despite the fact that the majority of human beings find endurance running an abnormal and entirely painful behavior, it has only continued to rise in popularity across people of all ages and abilities since the initial “running boom” of the 1970’s.

So, why do so many people participate in endurance/marathon running?  Perhaps one reason is because we are the only species that can. Continue reading

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My Daughter the Doctor

by Walter G. Wasser, MD

The world of medicine has now been open to women for decades. As parents, especially those in the medical field, recognize their daughters’ interests in medicine, they should encourage and support them as they pursue the long and difficult path toward their careers. Since the long years of medical school and clinical training typically coincide with a woman’s reproductive years, it is critical to foster a supportive environment where women can fulfill their academic aspirations without having to sacrifice the desire to start a family.

Here is the story of our daughter, Laurie. I hope that it can serve as an example of what a young woman can accomplish if nurtured and encouraged to achieve both goals – family and medicine – simultaneously.

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What’s in a p-value: science or magic?

by Anne Kessler

Upon completing my first year of graduate coursework, I found myself where no student wants to be – in a summer class. Per the stipulations of my training grant, I was enrolled in the Clinical Research Training Program’s summer intensive with a single goal in mind (pass) and very little appreciation for all that I would learn in the subsequent three months.

On the first day of introductory biostatistics, Einstein’s own Dr. Hillel Cohen discussed the use, misuse, and abuse of p-values in the scientific community.  He asked our class, which was composed of both students and clinicians, to provide a good definition for the term ‘p-value.’ He was not at all surprised when the best response we could provide was what he coined “a popular but entirely incorrect” definition of what a p-value actually is. For me, this raised feelings of concern and terror – How was it possible that a diverse room of researchers, all of whom use statistical methods to confirm that their research findings are relevant and significant, is incapable of collectively defining what a p-value is? At the end of the first lesson, Dr. Cohen wrote the definition of a p-value on the board: “A p-value is the calculated, estimated probability of observing the test statistic (or results more extreme) given that (1) the null hypothesis is true, (2) the assumptions of the test are not meaningfully violated, and (3) there is no systematic or differential random error.”

 

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Cogito, ergo sum homo? – (I think, therefore I am human?)

gorilla rodin

© Sergei Gladyshev /Hotspot Media

by Arthur Ruiz

What makes a person deserving of human rights? Is it something intrinsic in our nature, “endowed by [our] Creator with certain unalienable Rights”, as Thomas Jefferson wrote? Or is it simply the result of mutually-agreed-upon social conventions? Early humans defined “themselves” by their small tribal communities, and any outsiders were usually seen with a mix of suspicion and distrust. As societies began to develop and expand, the “in-group” of people consisted of villages, city-states, ethnic identities, and then nations. Even vaunted legal landmarks recognizing a certain baseline level of rights, like the Magna Carta or the Bill of Rights, still applied to a select group of “rights holders” (English nobles and property-holding white males, respectively). An important social achievement of the 20th and early 21st centuries has been the entrenchment of the idea that all human beings, regardless of their origins, beliefs or identities, are entitled to certain “inalienable” rights by virtue of their humanity.

The scope of this concept took an interesting turn this past April, when New York Supreme Court Justice Barbara Jaffe granted a writ of habeas corpus to two research chimpanzees, Hercules and Leo, who were being used for experiments in human cognition at Stony Brook University. This decision resulted from lawsuits filed by the Nonhuman Rights Project (NhRP), on behalf of four chimpanzees (the two Stony Brook ones, as well as two others held on private property), which made the argument that the chimpanzees should be considered “legal persons”, based on their advanced emotional and cognitive capabilities. The writ of habeas corpus granted to the chimpanzees did not by itself confer legal personhood (and Jaffe quickly amended her decision to remove the specific term “writ of habeas corpus”), but it was an important step towards the possible recognition as such. In practical terms, it legally obligated Stony Brook University to answer charges that Hercules and Leo had been “unlawfully detained”.

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From genome to transcriptome: new layers of gene expression

by Dulguun Amgalan

The field of molecular biology, as its name implies, is the study of life at the molecular scale. Living things are made of cells, and each one of these basic units of living matter is a complex molecular machine, in which macromolecules such as nucleic acids, polysaccharides and proteins interact together to generate a metabolic process we know as “life”. Although organisms are overwhelmingly diverse when observed from the outside, the fundamental molecular processes are essentially uniform, and it is this constancy that provides molecular biologists with the tools to understand how living things function.

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Transitions in Care: a medical student perspective

by Eva Catenaccio

“Have you had a bowel movement?” Ms. L smiled, shrugged, and pointed to her colostomy bag as if to say, “You tell me.” So began the first day of my internal medicine rotation as a third year medical student. My first patient was 83 years old and stuck in the hospital after a colon cancer surgery complicated by renal failure and pneumonia. I ended up following her for the next five weeks, spoon-feeding her lunch and bribing her for blood draws with ice chips I smuggled past the nurses.  Muted by a tracheostomy tube in her throat, she still had an emotional and expressive face. She smiled in delight at the ice chips, but winced and looked away when I struggled to find a vein.

Taking care of her, I learned how to harvest a sputum culture from her throat, how to apply the sequential compression devices to her calves, how to check the ventilator settings every morning and trace the tides of each breath in little green lines on the glowing monitor. I sat for many minutes holding her hand and trying to read her lips. She had worked years ago on that very wing of the hospital.  She had never learned to read or write. She had no family. One day she started to cry and could only mouth helplessly, “I’m afraid.”

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Health Disparities and Environmental Justice in the Bronx

by Danielle Pasquel

The direct link between socioeconomic status and human health has been well established in the field of public health. Poor communities face an array of distinct economic and social challenges that have quantifiably adverse effects on overall health and health outcomes. Many interrelated factors dictate the relationship between income and health, including sociopolitical status, access to and quality of healthcare, health literacy, nutritional awareness, stress management, and exposure to environmental hazards.

Health disparities in New York City (NYC) provide a perfect example. The Bronx, particularly the South Bronx, is the poorest congressional district in the country, and has some of the worse health outcomes in the nation—it isn’t difficult to see the connection. There is an overrepresentation of racial minorities in poorer communities—African Americans and Hispanics account for 43% and 54% of the South Bronx population, respectively (U.S. Census 2013). The community suffers from a host of health issues, including disproportionately high incidences of obesity, diabetes, asthma, cardiovascular disease, mental illness, and other chronic health conditions. Moreover, individuals from the Bronx are more likely to experience higher morbidity and mortality compared to white counterparts from middle-income or wealthier neighborhoods afflicted with the same disease, which is also the case nationwide. Continue reading

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The Impact of Bad Science

by Arthur Ruiz

A little bit of bad science can go a long way

Historians of science have always appreciated the collaborative efforts of communities of researchers, whose individual efforts can result in huge aggregate advances. For every revolutionary scientist like Isaac Newton or Nikola Tesla, who almost single-handedly changed the direction of their fields, there are numerous unsung scientists who have pushed a given discipline forward by their joint efforts. Newton and a few other Titans have planted entire mountains into the scientific landscape, while many others have resolutely contributed their pebbles. But pebbles can accumulate, and Newton himself was humble enough to observe: “If I have seen further, it is by standing on the shoulders of giants.” Scientists rely on the results and the insights of both predecessors and peers to drive their own studies forward. As contributors, however minute, to the collective edifice known as Science, we should therefore feel a special affront when we hear of an instance of scientific fraud or malfeasance.

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From Gin to Citizen Science

by Leah Guthrie

What we do in our free time often reflects our preoccupations. For a newly growing city like London in the eighteenth century, binge drinking gin served as a favored pastime; especially, among the developing working class who were adjusting from rural life to a crowded industrial society with poor working conditions. Gin was a very cheap antidote to the harsh realities of life with visibly numbing effects. At the height of the Gin Crisis in the 1720s, alcohol-related death rates were steadily climbing while birth rates were dropping to concerning levels. Laws restricting gin access did little to mitigate the damage until economic improvement generated a higher standard of living and new social pastimes, like coffee houses and restaurants that took advantage of the crowded and compact nature of city life (1).

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Porn Stars as Safe Sex Role Models? Measure B’s Educational Opportunity

Author’s name withheld by request

Many of us grow up emulating our favorite movie stars. But what if those movie stars were porn stars, and by acting like them we were preventing the spread of sexually transmitted diseases, such as gonorrhea and chlamydia? LA County lawmakers behind Measure B, or the “Safer Sex in the Adult Film Industry Act” perhaps had that idea.

In a recent study by Rodriguez-Hart et al., 28% of adult film actors in a 168-participant study were found to have chlamydia and/or gonorrhea 1.This statistic is more appalling when compared to the negligible percentage of legal prostitutes in Nevada with the aforementioned STDs 2. The study continued by describing how these diseases are transmitted, blaming unprotected oral and anal sex in addition to vaginal intercourse. Of the 47 (28%) participants with the STD, only 11 (23%) of them had STDs detectable through urogenital testing alone. In addition, over 90% of the oropharyngeal and rectal cases were asymptomatic. The study concluded that undiagnosed asymptomatic STDs were common and easily transmissible to sexual partners. The authors strongly believed that every performer should be tested for STDs at all anatomical sites and should have to use condoms for sex scenes. Measure B, which thoroughly addresses both of these concerns, was passed with 56% approval during the most recent election.

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