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Fluorescent microscopy (40X) of HeLa cells (cervix adenocarcinoma) undergoing chemotherapy. Nuclei in blue, beta-tubulin in green. Alterations in overall cellular morphology are visible.

Fluorescent microscopy (60X) of HeLa cells (cervix adenocarcinoma) after radiotherapy. Nuclei in blue, beta-tubulin in yellow, histone gamma-H2X in green. Histone gamma-H2X is marker of DNA damage/repair and it is clearly present in this cells after irradiation.

Fluorescent microscopy (40X) of PC3 cells (prostate adenocarcinoma) after radiotherapy. Nuclei in blue, beta-tubulin in green, phospho-survivin in red. Over-expression of p-survivin is a common mechanism employed by cancer cells to avoid apoptosis.

Histological section of murine small intestine (5X). Intestinal wall, cripts and villi are visible. Anti-BrdU immuno-staining (brown) reveals proliferating cells in the cripts.

Histological section of murine small intestine (10X). Intestinal wall, crypts and villi are visible. Anti-BrdU immuno-staining (brown) reveals proliferating cells in the crypts. This mouse underwent whole abdomen irradiation, thus intense proliferation in crypts.

Light microscopy (20X) of formalin-fixed HeLa cells 3 weeks after chemo-radiotherapy. Resistant clones with evident different cellular morphology are shown.